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CORANARY ARTERY SPASM

JJCC-501; No. of Pages 6 Journal of Cardiology (2012) xxx, xxx—xxx Available online at www.sciencedirect.com jou rnal h om epage: www.elsevier.com/locate/jjcc ORIGINAL ARTICLE Impact of low-dose aspirin on coronary artery spasm as assessed by intracoronary acetylcholine provocation test in Korean patients Ji Young Park (MD)a,b, Seung-Woon Rha (MD, PHD)a,∗, Kanhaiya L. Poddar (MD)a, Sureshkumar Ramasamy (MD, DM)a,c, Kang-Yin Chen (MD, PHD)a,d, Yong-Jian Li (MD, PHD)a,e, Byoung Geol Choia, Sung Kee Ryu (MD, PHD)b, Jae Woong Choi (MD, PHD)b, Sang Hyun Park (MD)b, Songree Park (MD)f, Amro Elnagar (MD)a, Sung Il Im (MD)a, Sun Won Kim (MD)a, Jin Oh Na (MD)a, Cheol Ung Choi (MD, PHD)a, Hong Euy Lim (MD, PHD)a, Jin Won Kim (MD, PHD)a, Eung Ju Kim (MD, PHD)a, Seong Woo Han (MD, PHD)a, Chang Gyu Park (MD, PHD)a, Hong Seog Seo (MD, PHD)a, Dong Joo Oh (MD, PHD)a a Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea b Cardiology Department, Eulji General Hospital, Eulji University, Seoul, Republic of Korea c Kovai Medical Centre and Hospital, Coimbatore, Tamilnadu, India d Cardiology Department, The Second Hospital of Tianjin Medical University, Tianjin, China e Cardiology Department, Nankai Hospital, Tianjin Medical University, Tianjin, China f Hanyang City International Clinic, Seoul, Republic of Korea Received 27 October 2011; received in revised form 14 February 2012; accepted 16 February 2012 KEYWORDS Aspirin; Acetylcholine; Coronary artery spasm Summary High-dose aspirin has been reported to aggravate coronary artery spasm (CAS). However, it is unknown whether low-dose aspirin (LDA; 100 mg) has deleterious impact on CAS. We assessed the impact of LDA on CAS induced by intracoronary acetylcholine (ACh) provocation test. A total of 2789 consecutive patients without significant coronary artery disease who underwent ACh test between November 2004 and March 2010 were enrolled. ∗ Corresponding author at: Cardiovascular Center, Korea University Guro Hospital, 80, Guro-dong, Guro-gu, Seoul 152-703, Republic of Korea. Tel.: +82 2 2626 3020; fax: +82 2 864 3062. E-mail address: swrha617@yahoo.co.kr (S.-W. Rha). 0914-5087/$ — see front matter © 2012 Japanese College of Cardiology.

Doctor Dr. Suresh Kumar Ramasamy, 2012071611:04:55



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